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Following the discovery that nicotine alters the expression of the PRM1 and PRM2 genes, further studies were conducted to investigate whether various nicotine products, such as smoking and hookah, had a different impact on the expression of these protamines [86, 96, 97, 104, 105, 106]

While debates over the possible long-term impact of e-cigarette use remain a subject of intense discussion, there is an overwhelming consensus that these products are significantly less harmful than cigarettes and can play an essential role in helping adult smokers quit

When this originates in the lungs, it is known as lung cancer