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Because of issues with resistance after repeated rounds (9) and for those not able to clear SIBO with antibiotics, natural antimicrobials have reported clearance rates over 50% in those who fail on Rifaximin (4)

GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)

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