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Therefore, it may be hypothesized that these processes could utilize similar mechanisms, i.e., the recapitulation hypothesis of remyelination (Franklin and Hinks, 1999)

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RGN-259 treatment promoted rapid healing of corneal epithelial defects, improved Mackie classification disease stage, and produced significant improvements in ocular discomfort, foreign body sensation, and dryness, with no significant adverse effects

Another previous study demonstrated that the genetic knockout of epithelial Wls suppressed the formation of hair placode and downregulated the expression levels of BMP2, BMP4, and SHH [36]