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Apathy related pathology Apathy in AD is most commonly associated with pathological changes of the anterior cingulate cortex (ACC), which include cortical thinning, atrophy, low fractional anisotropy (FA) scores, amyloid accumulation, hypometabolism, and neurofibrillary tangles (Tighe et al., 2012

Derivation of brain capillary-like endothelial cells from human pluripotent stem cell-derived endothelial progenitor cells

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These differences indicate that NAC decreases the build-up of sleep pressure across SD in males, whereas NAC accelerates the accumulation of sleep pressure during SD in female mice