Authors contributions AR, FK, EZ, HS, and SM contributed to the conception and design, as well as the acquisition, analysis, and interpretation of data
For example, whether mesangial cell ferroptosis contributes to glomerulosclerosis (a key feature of RF) or if renal endothelial ferroptosis exacerbates microvascular rarefaction and hypoxia (further amplifying RF) has not been systematically characterized
Additionally, the bioavailability of AS-IV in oral formulations remains a challenge, as the compound is poorly absorbed, which hinders its therapeutic potential in humans
The culmination of this effort was dihexa, a hydrophobic, N- and C-terminal modified, AnglV-related peptide