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Therefore the only way one could truly raise the reduced glutathione levels in the body was by undergoing costly direct intravenous administration of reduced glutathione

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Thus, having a certain percentage of HbS stabilized in the oxygenated state may prevent sickling thereof (Figure 1), a drug that binds covalently to the a-globin and stabilizes Hb in the oxygenated form (Vichinsky et al., 2019)

When fluid runs low, their ability to manage this workload drops, raising infection risk and metabolic stress on both mother and baby