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While acknowledging that further studies with shorter periods of preoperative smoking interventions were necessary, due to the difficulty of such a long period of abstinence for many smokers, this study made it very clear that the physicians and care team surrounding a smoking patient could have a significant and meaningful impact

In March 2022, Congress acted to close this loophole, setting new deadlines for the submission of PMTAs for synthetic products (May 14, 2022) and for FDA action on those applications (July 13, 2022)