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hypertension, type 2 DM, dyslipidemia) A meta-analysis of 22 trials involving over 17,000 patients determined that 50.2% and 17.5% of patients treated with GLP-1RAs (exenatide, semaglutide & liraglutide) experienced a weight loss of 5% and 10% compared to placebo, and that patients without type 2 diabetes achieved a significantly greater weight loss compared to those with diabetes (Vosoughi et al, 2022)

The Bottom Line: Can You Take Semaglutide and Tirzepatide Together Semaglutide and tirzepatide are both powerful medications used in medical weight management, but they are not typically taken together

This suggests a very good safety and tolerability profile indistinguishable from placebo in those trial settings

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