In addition, this enzyme was also found in the nucleolus of various cell types, such as human HeLa cells, mouse L929 cells (fibroblast cell line), but also in mouse testes, specifically in spermatogonia, spermatocytes and spermatids
Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme
Finally, 7 pathways grouped within the biosynthesis class were also significantly less abundant with an increase in NR, which were (I) the diacylglycerol biosynthesis III pathway, (II) and (III) the NAD salvage pathways I and V (PNC IV and V cycles), (IV) and (V) the phosphatidylglycerol biosynthesis I and II (plastidic non plastidic) pathways, (VI) the isoprene biosynthesis I pathway and (VII) the methylerythritol phosphate pathway II
Since enzymes that are able to inhibit or reduce hyperoxidation of Prx3, sulfiredoxin [160] , Grx2, and Trx2 [161] , are only partly correlated to ferroptosis [162] , the specificity of hyperoxidized Prx3 as a ferroptotic marker needs further investigation