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These findings challenge the notion that DSIPs primary role is sleep-related, prompting speculation about its wider impact on physiological processes

BioMed Res Int (2013) 2013:19

Cell and tissue damage associated with inflammation and, in the case of copper, also with oxidative stress, generates a number of immune-enhancing signals, including ROS and DAMP, that stimulate sentinel cells such as dendritic cells (DCs), macrophages, and monocytes, for antigen uptake and activation and then, migration to regional lymph nodes, where the antigen is presented to T and B lymphocytes