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Formulation choices vehicle, pH, penetration enhancers, concentration, and whether the peptide is stabilized against degradation can make the difference between a product that delivers an active dose and one that mostly sits on the surface
10.1093/jn/134.3.489 307 WuL
[12, 13, 14] Although this approach has mainly been used in cancer immunotherapy to activate cytotoxic T lymphocytes (CTLs) against tumor antigens, several immunogenic peptide therapeutics have been developed as well for autoimmune diseases including SLE, [15,16] rheumatoid arthritis, [17,18] type 1 diabetes, [19,20] and multiple sclerosis, [21] with varying success