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While this study was not designed to evaluate the mechanism, it seems to suggest that epigenetic changes could play a role, with reactive oxygen species appearing to be a key contributor that creates the primary source of damage, followed by secondary contributors

WO 2022/117884 A1, 9 June 2022 Lindbo JA, Dougherty WG (1992) Untranslatable transcripts of the tobacco etch virus coat protein gene sequence can interfere with tobacco etch virus replication in transgenic plants and protoplasts

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