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Yes, even occasional smoking and alcohol can have negative effects, though the risk is higher with regular or heavy use

Global, regional, and national liver cancer attributable to smoking and alcohol use burden, 19902021: analysis for the global burden of disease 2021 study

The smoking and driving laws and regulations were correct when this research was carried out between the 15th-19th of March 2021

In a review of studies looking at smoking cessation interventions for adults, nicotine patches improved continued abstinence from smoking at 6 months, and nicotine gum improved continued abstinence from smoking at 12 months