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According to the World Health Organization, its responsible for more than 7 million deaths each year

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A prominent feature of aging is cell cycle arrest, which exhibits the upregulation of genes that inhibit the cell cycle, such as p53 (also known as Trp53 or TP53 ), p21 ( Cdkn1a ), p16 , INK4A , and p19Arf , blocking the cell cycle and establishing an irreversible, stagnant state[40]

Curran Associates, Inc., Long Beach, California Lundberg SM, Erion G, Chen H, DeGrave A, Prutkin JM, Nair B, Katz R, Himmelfarb J, Bansal N, Lee S-I (2020) From local explanations to global understanding with explainable AI for trees