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Source: NIH Autonomic nervous system and digestion Why Smoking Anything Can Sometimes Make You Poop Anything Can Sometimes Make You Poop Smoking hemp, cannabis, tobacco, or even herbal blends can affect digestion because of: Posture changes (sitting/relaxing) Deep breathing Stress relief Timing (often after meals) Learned behavioral cues Its less about the substanceand more about how your body responds to the act of smoking