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In our study, experiments were performed using bulk populations, and the adaptive phenotypes were consistently reproduced across independent biological replicates and organoid systems, suggesting a population-level adaptive response under chronic WCSE conditions

These alternatives have gained popularity among individuals who want to quit traditional cigarettes or seek a smoking experience without nicotine

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Perfusion prior to exposure was similar between healthy controls and e-cigarette users, and following exposure, perfusion was increased ( Figure 9 (B) Spatial maps of ventilation, perfusion, and ventilation-perfusion ratios, before and after vaping, in a single sagittal slice of one representative subject