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Maternal tobacco smoking during pregnancy has been shown to significantly modulate placental miRNA expression, such as miR-16, miR-21 and miR-146a, potentially altering cellular differentiation, immune signaling and apoptotic pathways essential to fetal development (5)

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Another study published in Obesity Research & Clinical Practice (2014) confirmed that central fat accumulation was more pronounced in those who smoked, especially heavy smokers, compared to non-smokers