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For example, nicotine can activate the nAChRs on cancer cells and induce the release of growth factors, such as vascular endothelial growth factor (VEGF) and IL-1 into the tumor microenvironment, which can increase tumor angiogenesis and therefore promote tumor growth

For adults using the devices to quit smoking, the advice is to weigh all risks and benefits and consider using FDA-approved nicotine replacement therapies. One study found that people who use only e-cigarettes increase their risk of developing lung disease by about 30% compared with nonusers

PMC 3103484