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[52:13] It's a really great technology

HC Juncal: Nuria Caballero Ramrez, Ana Morn Escudero, Mercedes Rodrguez Franco, M Luz Meirio Prez, M Mar Zamora Gmez, Francisco Vivas Rubio, Mara Martn Martn

Semaglutide solves this problem through three key molecular modifications engineered to dramatically extend its biological activity while preserving high-affinity GLP-1 receptor (GLP-1R) binding: Amino acid substitution at position 8 Alanine is replaced with 2-aminoisobutyric acid (Aib) , making the molecule resistant to DPP-4 enzymatic degradation

In addition, these guidelines do not explicitly state whether this cut-off is expressed in NE base or salt formulation, an issue that is gaining in attention [14]