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Viral protein, nsp14 , interacts with the catalytic domain of Sirt1, dysregulates Nrf2/HO1 axis, and impairs host antioxidant defense 53

doi:10.4088/JCP.09m05324gre Williams JL, Everett JM, D'Cunha NM, et al

Such plant-based screening allows the simplified and controllable identification of regulatory nodes, particularly those linked to Ca 2+ and NO signalling, which are often difficult to dissect functionally in mammalian systems